InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ereg

Summary

InnateDB Protein

IDBP-179049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ereg

Protein Name

epiregulin

Synonyms

EPR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031324

InnateDB Gene

IDBG-179047 (Ereg)

Protein Structure

UniProt Annotation

Function

Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.

Subcellular Localization

Epiregulin: Secreted, extracellular space {ECO:0000250}.Proepiregulin: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001525	angiogenesis
GO:0001550	ovarian cumulus expansion
GO:0001556	oocyte maturation
GO:0001819	positive regulation of cytokine production
GO:0007143	female meiotic division
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009299	mRNA transcription
GO:0009653	anatomical structure morphogenesis
GO:0009887	organ morphogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0030728	ovulation
GO:0042108	positive regulation of cytokine biosynthetic process
GO:0042327	positive regulation of phosphorylation
GO:0042700	luteinizing hormone signaling pathway
GO:0043434	response to peptide hormone
GO:0043616	keratinocyte proliferation
GO:0045089	positive regulation of innate immune response
GO:0045410	positive regulation of interleukin-6 biosynthetic process
GO:0045740	positive regulation of DNA replication
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045840	positive regulation of mitosis
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048146	positive regulation of fibroblast proliferation
GO:0048160	primary follicle stage
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051151	negative regulation of smooth muscle cell differentiation
GO:0051781	positive regulation of cell division