InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ugt1a1

Summary

InnateDB Protein

IDBP-179175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ugt1a1

Protein Name

UDP glucuronosyltransferase 1 family, polypeptide A1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072803

InnateDB Gene

IDBG-488785 (Ugt1a1)

Protein Structure

UniProt Annotation

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Subcellular Localization

Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in liver and at lower levels in colon, kidney, stomach and intestine. {ECO:0000269PubMed:14672974}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0004857	enzyme inhibitor activity
GO:0005496	steroid binding
GO:0015020	glucuronosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0019899	enzyme binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001889	liver development
GO:0005975	carbohydrate metabolic process
GO:0006953	acute-phase response
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0010033	response to organic substance
GO:0014070	response to organic cyclic compound
GO:0030259	lipid glycosylation
GO:0031100	organ regeneration
GO:0032496	response to lipopolysaccharide
GO:0032870	cellular response to hormone stimulus
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0043086	negative regulation of catalytic activity
GO:0045471	response to ethanol
GO:0048545	response to steroid hormone
GO:0051384	response to glucocorticoid
GO:0051552	flavone metabolic process
GO:0052695	cellular glucuronidation
GO:0052696	flavonoid glucuronidation
GO:0052697	xenobiotic glucuronidation
GO:0070980	biphenyl catabolic process
GO:0071361	cellular response to ethanol
GO:0071385	cellular response to glucocorticoid stimulus
GO:2001030	negative regulation of cellular glucuronidation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070069	cytochrome complex