InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pparg

Summary

InnateDB Protein

IDBP-179255.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pparg

Protein Name

peroxisome proliferator activated receptor gamma

Synonyms

Nr1c3; PPAR-gamma; PPAR-gamma2; PPARgamma; PPARgamma2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000450

InnateDB Gene

IDBG-179253 (Pparg)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	32 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	104 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001012	RNA polymerase II regulatory region DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0030331	estrogen receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0033613	activating transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046965	retinoid X receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001890	placenta development
GO:0002674	negative regulation of acute inflammatory response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007507	heart development
GO:0008217	regulation of blood pressure
GO:0008285	negative regulation of cell proliferation
GO:0009409	response to cold
GO:0009612	response to mechanical stimulus
GO:0010033	response to organic substance
GO:0010871	negative regulation of receptor biosynthetic process
GO:0010887	negative regulation of cholesterol storage
GO:0010891	negative regulation of sequestering of triglyceride
GO:0014070	response to organic cyclic compound
GO:0015909	long-chain fatty acid transport
GO:0019216	regulation of lipid metabolic process
GO:0019395	fatty acid oxidation
GO:0030224	monocyte differentiation
GO:0030308	negative regulation of cell growth
GO:0030855	epithelial cell differentiation
GO:0031000	response to caffeine
GO:0031100	organ regeneration
GO:0032526	response to retinoic acid
GO:0032869	cellular response to insulin stimulus
GO:0032966	negative regulation of collagen biosynthetic process
GO:0033189	response to vitamin A
GO:0033993	response to lipid
GO:0035357	peroxisome proliferator activated receptor signaling pathway
GO:0035902	response to immobilization stress
GO:0036270	response to diuretic
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0042594	response to starvation
GO:0042953	lipoprotein transport
GO:0043065	positive regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043627	response to estrogen
GO:0045087	innate immune response (InnateDB)
GO:0045165	cell fate commitment
GO:0045444	fat cell differentiation
GO:0045598	regulation of fat cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045713	low-density lipoprotein particle receptor biosynthetic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046321	positive regulation of fatty acid oxidation
GO:0048469	cell maturation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0050872	white fat cell differentiation
GO:0050873	brown fat cell differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051974	negative regulation of telomerase activity
GO:0055098	response to low-density lipoprotein particle stimulus
GO:0060100	positive regulation of phagocytosis, engulfment
GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway
GO:0071285	cellular response to lithium ion
GO:0071300	cellular response to retinoic acid
GO:0071306	cellular response to vitamin E
GO:0071379	cellular response to prostaglandin stimulus
GO:0071380	cellular response to prostaglandin E stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071455	cellular response to hyperoxia
GO:1901558	response to metformin
GO:2000230	negative regulation of pancreatic stellate cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:97747

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003074 Peroxisome proliferator-activated receptor
IPR003077 Peroxisome proliferator-activated receptor, gamma
IPR008946 Nuclear hormone receptor, ligand-binding
IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal

PFAM

PF00104
PF00105
PF12577

PRINTS

PR00047
PR00398
PR01288
PR01291

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt