InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdca7

Summary

InnateDB Protein

IDBP-179691.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdca7

Protein Name

cell division cycle associated 7

Synonyms

2310021G01Rik; AU044109; JPO1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099752

InnateDB Gene

IDBG-179689 (Cdca7)

Protein Structure

UniProt Annotation

Function

Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-170 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0042127	regulation of cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1914203

InterPro

IPR018866 Zinc-finger domain of monoamine-oxidase A repressor R1

PFAM

PF10497

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D0M2

PhosphoSite

PhosphoSite-Q9D0M2

TrEMBL

UniProt Splice Variant

Entrez Gene

66953

UniGene

RefSeq

NP_080142

MGI ID

MGI Symbol

Cdca7

OMIM

CCDS

CCDS16121

HPRD

IMGT

EMBL

AK011289 AK028671 AK075882 AK153943 AK167734 BC066169

GenPept

AAH66169 BAB27519 BAC26058 BAC36027 BAE32269 BAE39775