InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ift122

Summary

InnateDB Protein

IDBP-179710.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ift122

Protein Name

intraflagellar transport 122 homolog (Chlamydomonas)

Synonyms

C86139; sopb; Wdr10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045468

InnateDB Gene

IDBG-179708 (Ift122)

Protein Structure

UniProt Annotation

Function

Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia. {ECO:0000269PubMed:19000668, ECO:0000269PubMed:21209331}.

Subcellular Localization

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to photoreceptor connecting cilia.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0001843	neural tube closure
GO:0007227	signal transduction downstream of smoothened
GO:0009953	dorsal/ventral pattern formation
GO:0010172	embryonic body morphogenesis
GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
GO:0035050	embryonic heart tube development
GO:0035115	embryonic forelimb morphogenesis
GO:0035720	intraciliary anterograde transport
GO:0035721	intraciliary retrograde transport
GO:0042733	embryonic digit morphogenesis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048593	camera-type eye morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060173	limb development
GO:0060271	cilium morphogenesis
GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0060971	embryonic heart tube left/right pattern formation
GO:0061512	protein localization to cilium
GO:0072594	establishment of protein localization to organelle

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030991	intraciliary transport particle A
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body
GO:0072372	primary cilium