InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cir1

Summary

InnateDB Protein

IDBP-179951.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cir1

Protein Name

corepressor interacting with RBPJ, 1

Synonyms

1700023B02Rik; 2810021A19Rik; Cicr; Cir;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049834

InnateDB Gene

IDBG-179947 (Cir1)

Protein Structure

UniProt Annotation

Function

Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre-mRNAs. {ECO:0000250, ECO:0000269PubMed:15652350}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:15652350}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with NEK6 in the centrosome. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter