InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plxnd1

Summary

InnateDB Protein

IDBP-179968.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plxnd1

Protein Name

plexin D1

Synonyms

6230425C21Rik; b2b1863Clo; b2b553Clo;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015511

InnateDB Gene

IDBG-179964 (Plxnd1)

Protein Structure

UniProt Annotation

Function

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Mediates anti-angiogenic signaling in response to SEMA3E. Required for normal development of the heart and vasculature. {ECO:0000269PubMed:15239958, ECO:0000269PubMed:17318185, ECO:0000269PubMed:18992737, ECO:0000269PubMed:19027330, ECO:0000269PubMed:19421194, ECO:0000269PubMed:22179111}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17318185, ECO:0000269PubMed:19027330}; Single-pass membrane protein {ECO:0000269PubMed:17318185, ECO:0000269PubMed:19027330}.

Disease Associations

Tissue Specificity

Detected in embryonic heart and vascular endothelium, brain, dorsal root ganglia, adrenal gland, lung mesenchyme, small intestine and in the ossification centers of vertebral bodies. {ECO:0000269PubMed:18992737}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity
GO:0019904	protein domain specific binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0003151	outflow tract morphogenesis
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007416	synapse assembly
GO:0030334	regulation of cell migration
GO:0032092	positive regulation of protein binding
GO:0043542	endothelial cell migration
GO:0045765	regulation of angiogenesis
GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching
GO:0071526	semaphorin-plexin signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

MGI:2154244

InterPro

IPR001627 Sema domain
IPR002165 Plexin
IPR002909 IPT domain
IPR008936 Rho GTPase activation protein
IPR013548 Plexin, cytoplasmic RasGAP domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold

PFAM

PF01403
PF01437
PF01833
PF08337

PRINTS

PIRSF

SMART

SM00630
SM00429
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UH93