InnateDB Protein
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IDBP-180026.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Itm2b
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Protein Name
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integral membrane protein 2B
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Synonyms
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AI256040; Bri; Bri2; Bricd2b; D14Sel6; E25BMM; imBRI2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022704
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InnateDB Gene
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IDBG-180024 (Itm2b)
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Protein Structure
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Function |
Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity). {ECO:0000250}.Mature BRI2 (mBRI2) functions as a modulator of the beta-amyloid A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed beta- amyloid protein 40 and beta-amyloid protein 42. {ECO:0000250}.Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers. {ECO:0000250}.
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Subcellular Localization |
Integral membrane protein 2B: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Immature BRI2 (imBRI2) is cleaved by furin in the Golgi into mBRI2 and a Bri23 peptide. mBRI2 is transported to the plasma membrane and Bri23 peptide is secreted (By similarity). {ECO:0000250}.BRI2, membrane form: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Mature BRI2 (mBRI2) needs to be transported from the endoplasmic reticulum compartment to the cell membrane in order to be able to inhibit APP processing. {ECO:0000250}.Bri23 peptide: Secreted {ECO:0000250}. Note=Detected in the cerebral spinal fluid (CSF). {ECO:0000250}.BRI2C, soluble form: Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0042985
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negative regulation of amyloid precursor protein biosynthetic process
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GO:0097192
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extrinsic apoptotic signaling pathway in absence of ligand
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Cellular Component |
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PDB ID |
MGI:1309517
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InterPro |
IPR007084
BRICHOS domain
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PFAM |
PF04089
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PRINTS |
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PIRSF |
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SMART |
SM01039
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TIGRFAMs |
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Modification |
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SwissProt |
O89051
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PhosphoSite |
PhosphoSite-O89051
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TrEMBL |
Q9JME4
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UniProt Splice Variant |
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Entrez Gene |
16432
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UniGene |
Mm.4266
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RefSeq |
NP_032436
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MGI ID |
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MGI Symbol |
Itm2b
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OMIM |
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CCDS |
CCDS27269
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HPRD |
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IMGT |
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EMBL |
AB030203
AB030204
AK002599
AK003587
AK005125
AK008861
AK076139
AK077482
AK150378
AK151714
AK151889
AK152068
AK152516
AK152650
AK152731
AK152983
AK153103
AK159340
AK159426
AK159619
AK159628
AK159792
AK159962
AK160725
BC004731
BC010320
BC021786
U76253
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GenPept |
AAC63851
AAH04731
AAH10320
AAH21786
BAA92766
BAA92767
BAB22220
BAB22877
BAB23828
BAB25935
BAC36212
BAC36822
BAE29510
BAE30633
BAE30773
BAE30922
BAE31278
BAE31387
BAE31452
BAE31632
BAE31723
BAE35002
BAE35073
BAE35235
BAE35242
BAE35374
BAE35517
BAE35970
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