InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chrna1

Summary

InnateDB Protein

IDBP-180258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrna1

Protein Name

cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)

Synonyms

Achr-1; Acra; AI385656; AI608266;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028515

InnateDB Gene

IDBG-180256 (Chrna1)

Protein Structure

UniProt Annotation

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding
GO:0015464	acetylcholine receptor activity
GO:0042166	acetylcholine binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007274	neuromuscular synaptic transmission
GO:0007528	neuromuscular junction development
GO:0019228	neuronal action potential
GO:0034220	ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0046716	muscle cell cellular homeostasis
GO:0048630	skeletal muscle tissue growth
GO:0050881	musculoskeletal movement
GO:0050905	neuromuscular process
GO:0070050	neuron cellular homeostasis

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0031594	neuromuscular junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:87885

InterPro

IPR002394 Nicotinic acetylcholine receptor
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR00254
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P04756