InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrrfip1

Summary

InnateDB Protein

IDBP-180431.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrrfip1

Protein Name

leucine rich repeat (in FLII) interacting protein 1

Synonyms

AU024550; Fliiap1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095255

InnateDB Gene

IDBG-180425 (Lrrfip1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA (By similarity). Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:9525888}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1342770

InterPro

IPR019139 Leucine-rich repeat flightless-interacting protein

PFAM

PF09738

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UZ39

PhosphoSite

PhosphoSite-Q3UZ39

TrEMBL

UniProt Splice Variant

Entrez Gene

16978

UniGene

Mm.467997

RefSeq

NP_032541

MGI ID

MGI Symbol

Lrrfip1

OMIM

CCDS

CCDS35662

HPRD

IMGT

EMBL

AF045573 AK134120 AK162191

GenPept

AAC40072 BAE22022 BAE36781