InnateDB Protein
|
IDBP-180706.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Ube2f
|
Protein Name
|
ubiquitin-conjugating enzyme E2F (putative)
|
Synonyms
|
2510010F15Rik; AI851109;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000054303
|
InnateDB Gene
|
IDBG-180704 (Ube2f)
|
Protein Structure
|
|
Function |
Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. {ECO:0000269PubMed:19250909}.
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
Widely expressed (at protein level). {ECO:0000269PubMed:19250909}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
14 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1915171
|
InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
|
PFAM |
PF00179
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9CY34
|
PhosphoSite |
PhosphoSite-Q9CY34
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
67921
|
UniGene |
Mm.487108
|
RefSeq |
XP_006529899
|
MGI ID |
|
MGI Symbol |
Ube2f
|
OMIM |
|
CCDS |
CCDS48322
|
HPRD |
|
IMGT |
|
EMBL |
AK007937
AK007960
AK010957
AK030594
AK153481
BC006057
BC016117
|
GenPept |
AAH06057
AAH16117
BAB25362
BAB25372
BAB27290
BAC27036
BAE32030
|
|
|