Version 5.4
Mus musculus Protein: Zfp422
Summary
InnateDB Protein IDBP-180843.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfp422
Protein Name zinc finger protein 422
Synonyms 2900028O21Rik; AU041373; KOX15; Krox-25-2; Krox-26; Krox25; Krox26; Znf22;
Species Mus musculus
Ensembl Protein ENSMUSP00000078685
InnateDB Gene IDBG-180841 (Zfp422)
Protein Structure
UniProt Annotation
Function Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation. {ECO:0000269PubMed:12952191, ECO:0000303PubMed:12489153}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed predominantly in developing craniofacial bones and dental organs, and in molar tooth germs of postnatal animals. Also detected in embryonic heart, liver, thymus, kidney, brain, lung, muscle and calvaria. In the adult, highly expressed in lung, kidney, bone and incisors. {ECO:0000269PubMed:12489153, ECO:0000269PubMed:12952191, ECO:0000269PubMed:14706453}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0042476 odontogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1914505
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ERU3
PhosphoSite PhosphoSite-Q9ERU3
TrEMBL
UniProt Splice Variant
Entrez Gene 67255
UniGene Mm.406226
RefSeq NP_080333
MGI ID
MGI Symbol Zfp422
OMIM
CCDS CCDS20459
HPRD
IMGT
EMBL AF281634 AK082970 AK169251 BC018339
GenPept AAG12466 AAH18339 BAC38716 BAE41015

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca