InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddn

Summary

InnateDB Protein

IDBP-181314.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddn

Protein Name

dendrin

Synonyms

Gm748;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074895

InnateDB Gene

IDBG-181312 (Ddn)

Protein Structure

UniProt Annotation

Function

Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein. {ECO:0000269PubMed:17537921}.

Subcellular Localization

Cell projection, dendritic spine membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Perikaryon {ECO:0000250}. Nucleus. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites. {ECO:0000250}.

Disease Associations

Tissue Specificity

Two forms of 81 kDa and 89 kDa are expressed in brain. The 81 kDa form is the only one found in kidney podocytes. {ECO:0000269PubMed:17251388, ECO:0000269PubMed:17537921}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0030425	dendrite
GO:0032591	dendritic spine membrane
GO:0042995	cell projection
GO:0043204	perikaryon