InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Emx2

Summary

InnateDB Protein

IDBP-181329.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Emx2

Protein Name

empty spiracles homolog 2 (Drosophila)

Synonyms

Pdo;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053361

InnateDB Gene

IDBG-181327 (Emx2)

Protein Structure

UniProt Annotation

Function

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. {ECO:0000269PubMed:1352754, ECO:0000269PubMed:15147765}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Cerebral cortex. {ECO:0000269PubMed:1352754}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007420	brain development
GO:0009952	anterior/posterior pattern specification
GO:0010468	regulation of gene expression
GO:0021542	dentate gyrus development
GO:0021796	cerebral cortex regionalization
GO:0021846	cell proliferation in forebrain
GO:0021885	forebrain cell migration
GO:0021987	cerebral cortex development
GO:0030182	neuron differentiation
GO:0030900	forebrain development
GO:0042493	response to drug
GO:0072001	renal system development