InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Traf3ip1

Summary

InnateDB Protein

IDBP-181371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Traf3ip1

Protein Name

TRAF3 interacting protein 1

Synonyms

3930402D05Rik; AU041749; MIP-T3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042391

InnateDB Gene

IDBG-181369 (Traf3ip1)

Protein Structure

UniProt Annotation

Function

Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, cilium {ECO:0000269PubMed:19253336}. Note=Microtubules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0021532	neural tube patterning
GO:0031076	embryonic camera-type eye development
GO:0032688	negative regulation of interferon-beta production
GO:0035050	embryonic heart tube development
GO:0036342	post-anal tail morphogenesis
GO:0042073	intraciliary transport
GO:0042384	cilium assembly
GO:0042733	embryonic digit morphogenesis
GO:0050687	negative regulation of defense response to virus
GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning