InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ogfod1

Summary

InnateDB Protein

IDBP-181417.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ogfod1

Protein Name

2-oxoglutarate and iron-dependent oxygenase domain containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090991

InnateDB Gene

IDBG-181415 (Ogfod1)

Protein Structure

UniProt Annotation

Function

Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit RPS23, thereby regulating protein translation termination efficiency. Involved in stress granule formation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding
GO:0031543	peptidyl-proline dioxygenase activity
GO:0031544	peptidyl-proline 3-dioxygenase activity

Biological Process

GO:0006449	regulation of translational termination
GO:0008283	cell proliferation
GO:0018126	protein hydroxylation
GO:0019511	peptidyl-proline hydroxylation
GO:0034063	stress granule assembly
GO:0055114	oxidation-reduction process