Version 5.4
Mus musculus Protein: Phex
Summary
InnateDB Protein IDBP-181591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phex
Protein Name phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)
Synonyms Gy; HPDR; HPDR1; Hyp; PEX;
Species Mus musculus
Ensembl Protein ENSMUSP00000078863
InnateDB Gene IDBG-181589 (Phex)
Protein Structure
UniProt Annotation
Function Probably involved in bone and dentin mineralization and renal phosphate reabsorption.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Bone.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0019637 organophosphate metabolic process
GO:0030282 bone mineralization
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:107489
InterPro IPR008753 Peptidase M13, N-terminal domain
IPR018497 Peptidase M13, C-terminal domain
PFAM PF05649
PF01431
PRINTS PR00786
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70669
PhosphoSite PhosphoSite-P70669
TrEMBL Q9ERK6
UniProt Splice Variant
Entrez Gene 18675
UniGene Mm.429046
RefSeq NP_035207
MGI ID
MGI Symbol Phex
OMIM
CCDS CCDS30497
HPRD
IMGT
EMBL AF299334 AK158481 AL663072 AL808135 BC137925 BC137926 CH466571 CT572987 CU915265 CU915273 U49908 U73910 U73911 U73912 U73913 U73914 U73915 U75646
GenPept AAB47750 AAC25962 AAC25963 AAC25964 AAC25965 AAC25966 AAC25967 AAC36502 AAG24632 AAI37926 AAI37927 BAE34533 EDL40838

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca