InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndufa10

Summary

InnateDB Protein

IDBP-181721.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufa10

Protein Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10

Synonyms

2900053E13Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027478

InnateDB Gene

IDBG-181719 (Ndufa10)

Protein Structure

UniProt Annotation

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0008150	biological_process
GO:0042493	response to drug
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005747	mitochondrial respiratory chain complex I
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:1914523

InterPro

IPR002624 Deoxynucleoside kinase
IPR015828 NADH:ubiquinone oxidoreductase, 42kDa subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01712

PRINTS

PIRSF

PIRSF000705
PIRSF000543

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99LC3