Version 5.4
| Mus musculus Protein: Mbtps2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Protein | IDBP-181726.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Mbtps2 | ||||||||
| Protein Name | membrane-bound transcription factor peptidase, site 2 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000059471 | ||||||||
| InnateDB Gene | IDBG-181722 (Mbtps2) | ||||||||
| Protein Structure |
|
||||||||
| UniProt Annotation | |||||||||
| Function | Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2444506 | ||||||||
| InterPro |
IPR001193
Membrane-bound transcription factor site-2 protease IPR001478 PDZ domain IPR008915 Peptidase M50 |
||||||||
| PFAM |
PF00595
PF13180 PF02163 |
||||||||
| PRINTS |
PR01000
|
||||||||
| PIRSF | |||||||||
| SMART |
SM00228
|
||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8CHX6 | ||||||||
| PhosphoSite | PhosphoSite-Q8CHX6 | ||||||||
| TrEMBL | A2AC84 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 270669 | ||||||||
| UniGene | Mm.488262 | ||||||||
| RefSeq | NP_758511 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Mbtps2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS30498 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK148325 AK164486 AL663072 BC038343 | ||||||||
| GenPept | AAH38343 BAE28482 BAE37807 CAM18093 | ||||||||