InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnajc15

Summary

InnateDB Protein

IDBP-181934.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnajc15

Protein Name

DnaJ (Hsp40) homolog, subfamily C, member 15

Synonyms

1110003P16Rik; Dnajd1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022590

InnateDB Gene

IDBG-181932 (Dnajc15)

Protein Structure

UniProt Annotation

Function

Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9 (By similarity). Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP. {ECO:0000250, ECO:0000269PubMed:23530063}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:23530063}; Single-pass membrane protein {ECO:0000269PubMed:23530063}.

Disease Associations

Tissue Specificity

Expressed at high levels in liver, heart, at moderate levels in kidney and, at very low levels, in lung (at protein level). High expression levels in testis. Highly expressed in CD8+ T-cells, but barely detectable in CD4+ T-cells (at protein level). Almost undetectable in B-cells. {ECO:0000269PubMed:23530063}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0009267	cellular response to starvation
GO:0015031	protein transport
GO:0019216	regulation of lipid metabolic process
GO:0031333	negative regulation of protein complex assembly
GO:1902957	negative regulation of mitochondrial electron transport, NADH to ubiquinone