InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tuba1b

Summary

InnateDB Protein

IDBP-181940.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tuba1b

Protein Name

tubulin, alpha 1B

Synonyms

Tuba2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076777

InnateDB Gene

IDBG-181938 (Tuba1b)

Protein Structure

UniProt Annotation

Function

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Ubiquitously expressed with highest levels in spleen, thymus and immature brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0003924	GTPase activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0006184	GTP catabolic process
GO:0006457	protein folding
GO:0051258	protein polymerization
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005829	cytosol
GO:0005874	microtubule
GO:0005881	cytoplasmic microtubule
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:107804

InterPro

IPR000217 Tubulin
IPR002452 Alpha tubulin
IPR002453 Beta tubulin
IPR002967 Delta tubulin
IPR003008 Tubulin/FtsZ, GTPase domain
IPR004057 Epsilon tubulin
IPR008280 Tubulin/FtsZ, C-terminal
IPR018316 Tubulin/FtsZ, 2-layer sandwich domain

PFAM

PF00091
PF03953

PRINTS

PR01161
PR01162
PR01163
PR01224
PR01519

PIRSF

SMART

SM00864
SM00865

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt