Version 5.4
Mus musculus Protein: Pth2
Summary
InnateDB Protein IDBP-181989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pth2
Protein Name parathyroid hormone 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000041047
InnateDB Gene IDBG-181987 (Pth2)
Protein Structure
UniProt Annotation
Function Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. {ECO:0000269PubMed:11818570, ECO:0000269PubMed:11861531, ECO:0000269PubMed:12084532}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in testis and, less abundantly, in liver and kidney. Expressed in seminiferous tubuli and several brain regions, including nucleus ruber, caudal paralemniscal nucleus, nucleus centralis pontis, and nucleus subparafascicularis thalami. Expressed in neurons of cerebral cortex and subcortical areas. Expressed in Purkinje cells of cerebellum. {ECO:0000269PubMed:11818570, ECO:0000269PubMed:11861531, ECO:0000269PubMed:12098667}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
Biological Process
GO:0006171 cAMP biosynthetic process
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:2152297
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91W27
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 114640
UniGene Mm.207078
RefSeq NP_444486
MGI ID
MGI Symbol Pth2
OMIM
CCDS CCDS21233
HPRD
IMGT
EMBL AF399674 AY048587
GenPept AAK84862 AAL06596

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca