InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfsf11

Summary

InnateDB Protein

IDBP-182103.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfsf11

Protein Name

tumor necrosis factor (ligand) superfamily, member 11

Synonyms

Ly109l; ODF; OPG; OPGL; RANKL; Trance;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022592

InnateDB Gene

IDBG-182101 (Tnfsf11)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type II membrane protein.Isoform 2: Cell membrane; Single-pass type II membrane protein.Isoform 3: Cytoplasm.Tumor necrosis factor ligand superfamily member 11, soluble form: Secreted.

Disease Associations

Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.

Tissue Specificity

Highly expressed in thymus and lymph nodes, but not in non-lymphoid tissues and is abundantly expressed in T- cells but not in B-cells. A high level expression is also seen in the trabecular bone and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0032813	tumor necrosis factor receptor superfamily binding

Biological Process

GO:0001503	ossification
GO:0002158	osteoclast proliferation
GO:0002548	monocyte chemotaxis
GO:0006955	immune response
GO:0007257	activation of JUN kinase activity
GO:0009887	organ morphogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0030316	osteoclast differentiation
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0033598	mammary gland epithelial cell proliferation
GO:0034112	positive regulation of homotypic cell-cell adhesion
GO:0042327	positive regulation of phosphorylation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045453	bone resorption
GO:0045670	regulation of osteoclast differentiation
GO:0045672	positive regulation of osteoclast differentiation
GO:0045780	positive regulation of bone resorption
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0048535	lymph node development
GO:0050870	positive regulation of T cell activation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051260	protein homooligomerization
GO:0051466	positive regulation of corticotropin-releasing hormone secretion
GO:0051897	positive regulation of protein kinase B signaling
GO:0055074	calcium ion homeostasis
GO:0060749	mammary gland alveolus development
GO:0070371	ERK1 and ERK2 cascade
GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847	TNFSF11-mediated signaling pathway
GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
GO:1902533	positive regulation of intracellular signal transduction
GO:2001206	positive regulation of osteoclast development

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane