Homo sapiens Protein: PRKAA1
Summary
InnateDB Protein IDBP-18232.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKAA1
Protein Name protein kinase, AMP-activated, alpha 1 catalytic subunit
Synonyms AMPK; AMPKa1;
Species Homo sapiens
Ensembl Protein ENSP00000296800
InnateDB Gene IDBG-18226 (PRKAA1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 144 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 144 [view]
Protein-Protein 141 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000187 activation of MAPK activity
GO:0006468 protein phosphorylation
Cellular Component
GO:0031588 AMP-activated protein kinase complex
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q96E92
UniProt Splice Variant
Entrez Gene 5562
UniGene Hs.602424
RefSeq
HUGO HGNC:9376
OMIM 602739
CCDS
HPRD 04115
IMGT
EMBL AC008810 BC012622 CH471119
GenPept AAH12622 EAW56001