InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmp3

Summary

InnateDB Protein

IDBP-182411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmp3

Protein Name

bone morphogenetic protein 3

Synonyms

9130206H07; 9530029I04Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031278

InnateDB Gene

IDBG-182409 (Bmp3)

Protein Structure

UniProt Annotation

Function

Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. {ECO:0000269PubMed:11138004}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008083	growth factor activity
GO:0070700	BMP receptor binding

Biological Process

GO:0001503	ossification
GO:0030154	cell differentiation
GO:0040007	growth
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development

Cellular Component

GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:88179

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR017197 Bone morphogenetic protein 3/growth differentiation factor 10
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PIRSF

PIRSF037403

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt