InnateDB Protein
|
IDBP-182655.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Lepre1
|
Protein Name
|
leprecan 1
|
Synonyms
|
2410024C15Rik; Gros1; P3H1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000080312
|
InnateDB Gene
|
IDBG-182649 (Lepre1)
|
Protein Structure
|
|
Function |
Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Endoplasmic reticulum {ECO:0000255PROSITE- ProRule:PRU10138}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan (CSPG).
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
8 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0005506
|
iron ion binding
|
GO:0016491
|
oxidoreductase activity
|
GO:0016705
|
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
|
GO:0016706
|
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
|
GO:0019797
|
procollagen-proline 3-dioxygenase activity
|
GO:0031418
|
L-ascorbic acid binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1888921
|
InterPro |
IPR005123
Oxoglutarate/iron-dependent dioxygenase
IPR006620
Prolyl 4-hydroxylase, alpha subunit
|
PFAM |
PF03171
PF13640
|
PRINTS |
|
PIRSF |
|
SMART |
SM00702
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q3V1T4
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
56401
|
UniGene |
Mm.27961
|
RefSeq |
NP_001035874
|
MGI ID |
|
MGI Symbol |
Lepre1
|
OMIM |
|
CCDS |
CCDS38860
|
HPRD |
|
IMGT |
|
EMBL |
AF165163
AF165164
AK010578
AK030436
AK132262
AK159505
AL606975
BC024047
|
GenPept |
AAF04806
AAF04807
AAH24047
BAB27041
BAC26962
BAE21065
BAE35138
CAM21645
CAO78098
|
|
|