Version 5.4
Mus musculus Protein: Wbp4
Summary
InnateDB Protein IDBP-182802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wbp4
Protein Name WW domain binding protein 4
Synonyms AW545037; BB101031; FBP21;
Species Mus musculus
Ensembl Protein ENSMUSP00000022601
InnateDB Gene IDBG-182800 (Wbp4)
Protein Structure
UniProt Annotation
Function Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex. {ECO:0000269PubMed:9724750}.
Subcellular Localization Nucleus speckle {ECO:0000255PROSITE- ProRule:PRU00130, ECO:0000269PubMed:9724750}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0070064 proline-rich region binding
Biological Process
GO:0045292 mRNA cis splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005886 plasma membrane
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:109568
InterPro IPR000690 Zinc finger, C2H2-type matrin
IPR001202 WW domain
IPR003604 Zinc finger, U1-type
IPR013085 Zinc finger, U1-C type
PFAM PF00397
PF06220
PRINTS
PIRSF
SMART SM00456
SM00451
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61048
PhosphoSite PhosphoSite-Q61048
TrEMBL Q78E74
UniProt Splice Variant
Entrez Gene 22380
UniGene Mm.416488
RefSeq NP_061235
MGI ID
MGI Symbol Wbp4
OMIM
CCDS CCDS27300
HPRD
IMGT
EMBL AF071184 AK019160 AK135215 AK160559 AK162009 BC034851 CH466535 U40746
GenPept AAC34810 AAC52474 AAH34851 BAB31575 BAE22462 BAE35873 BAE36679 EDL35764

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca