InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snrnp70

Summary

InnateDB Protein

IDBP-182808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snrnp70

Protein Name

small nuclear ribonucleoprotein 70 (U1)

Synonyms

2700022N21Rik; 3200002N22Rik; 70kDa; AI325098; R74807; Rnulp70; Snrp70; Srnp70; U1-70; U1-70K;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074160

InnateDB Gene

IDBG-182806 (Snrnp70)

Protein Structure

UniProt Annotation

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:17656373}. Nucleus, nucleoplasm {ECO:0000269PubMed:17656373}. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding