Version 5.4
Mus musculus Protein: Dok4
Summary
InnateDB Protein IDBP-182848.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dok4
Protein Name docking protein 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000043554
InnateDB Gene IDBG-182846 (Dok4)
Protein Structure
UniProt Annotation
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed. Highest levels in heart, lung and kidney. {ECO:0000269PubMed:11470823}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0000165 MAPK cascade
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
Cellular Component
Protein Structure and Domains
PDB ID MGI:2148865
InterPro IPR001849 Pleckstrin homology domain
IPR002404 Insulin receptor substrate-1, PTB
PFAM PF00169
PF02174
PRINTS PR00628
PIRSF
SMART SM00233
SM00310
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99KE3
PhosphoSite PhosphoSite-Q99KE3
TrEMBL
UniProt Splice Variant
Entrez Gene 114255
UniGene Mm.203949
RefSeq NP_444476
MGI ID
MGI Symbol Dok4
OMIM
CCDS CCDS40443
HPRD
IMGT
EMBL AF418207 AK032352 AK043670 AK142621 AK156485 BC004705
GenPept AAH04705 AAL14626 BAC27829 BAC31613 BAE25134 BAE33728

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca