InnateDB Protein
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IDBP-182927.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ybx1
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Protein Name
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Y box protein 1
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Synonyms
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1700102N10Rik; C79409; dbpB; EF1A; MSY1; mYB-1a; Nsep1; YB-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000078589
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InnateDB Gene
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IDBG-182925 (Ybx1)
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Protein Structure
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Function |
Mediates pre-mRNA alternative splicing regulation. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds preferentially to 5'-[CU]CUGCG-3' motif in vitro (By similarity). {ECO:0000250}.The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Secreted {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed at high levels in the testis. Present in the mRNP particles that mediate the storage and masking of mRNAs during spermiogenesis. {ECO:0000269PubMed:8505341}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 112 interaction(s) predicted by orthology.
Experimentally validated |
Total |
85
[view]
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Protein-Protein |
84
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
112 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:99146
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InterPro |
IPR002059
Cold-shock protein, DNA-binding
IPR011129
Cold shock protein
IPR012340
Nucleic acid-binding, OB-fold
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PFAM |
PF00313
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PRINTS |
PR00050
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PIRSF |
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SMART |
SM00357
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TIGRFAMs |
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Modification |
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SwissProt |
P62960
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PhosphoSite |
PhosphoSite-P62960
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TrEMBL |
Q8BRJ5
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UniProt Splice Variant |
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Entrez Gene |
22608
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UniGene |
Mm.399853
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RefSeq |
NP_035862
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MGI ID |
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MGI Symbol |
Ybx1
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OMIM |
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CCDS |
CCDS18579
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HPRD |
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IMGT |
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EMBL |
AK044081
AK150821
BC013450
BC013620
BC029747
BC031472
BC061634
BC106143
M60419
M62867
X57621
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GenPept |
AAA40577
AAA63390
AAH13450
AAH13620
AAH29747
AAH31472
AAH61634
AAI06144
BAC31766
BAE29883
CAA40847
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