Mus musculus Protein: Ybx1
InnateDB Protein IDBP-182927.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ybx1
Protein Name Y box protein 1
Synonyms 1700102N10Rik; C79409; dbpB; EF1A; MSY1; mYB-1a; Nsep1; YB-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000078589
InnateDB Gene IDBG-182925 (Ybx1)
Protein Structure
UniProt Annotation
Function Mediates pre-mRNA alternative splicing regulation. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds preferentially to 5'-[CU]CUGCG-3' motif in vitro (By similarity). {ECO:0000250}.The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Secreted {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at high levels in the testis. Present in the mRNP particles that mediate the storage and masking of mRNAs during spermiogenesis. {ECO:0000269PubMed:8505341}.
Number of Interactions This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 112 interaction(s) predicted by orthology.
Experimentally validated
Total 85 [view]
Protein-Protein 84 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 112 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045087 innate immune response (InnateDB)
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0051781 positive regulation of cell division
GO:0070934 CRD-mediated mRNA stabilization
Cellular Component
GO:0005634 nucleus
GO:0005689 U12-type spliceosomal complex
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0030529 ribonucleoprotein complex
GO:0031965 nuclear membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
GO:0070937 CRD-mediated mRNA stability complex
GO:0071204 histone pre-mRNA 3'end processing complex
Protein Structure and Domains
PDB ID MGI:99146
InterPro IPR002059 Cold-shock protein, DNA-binding
IPR011129 Cold shock protein
IPR012340 Nucleic acid-binding, OB-fold
PFAM PF00313
Post-translational Modifications
SwissProt P62960
PhosphoSite PhosphoSite-P62960
UniProt Splice Variant
Entrez Gene 22608
UniGene Mm.399853
RefSeq NP_035862
MGI Symbol Ybx1
EMBL AK044081 AK150821 BC013450 BC013620 BC029747 BC031472 BC061634 BC106143 M60419 M62867 X57621
GenPept AAA40577 AAA63390 AAH13450 AAH13620 AAH29747 AAH31472 AAH61634 AAI06144 BAC31766 BAE29883 CAA40847