InnateDB Protein
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IDBP-183047.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Lect1
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Protein Name
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leukocyte cell derived chemotaxin 1
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Synonyms
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Bricd3; ChM-I;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022603
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InnateDB Gene
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IDBG-183045 (Lect1)
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Protein Structure
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Function |
Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development (By similarity). Inhibits in vitro tube formation and mobilization of endothelial cells (By similarity). Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. {ECO:0000250, ECO:0000269PubMed:16980969}.
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Subcellular Localization |
Chondromodulin-1: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Accumulated in the inter-territorial matrix of cartilage. {ECO:0000250}.Chondrosurfactant protein: Endomembrane system {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Detected in the four cardiac valves, valvular interstitial cells and extracellular matrix (at protein level). {ECO:0000269PubMed:16980969}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0001886
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endothelial cell morphogenesis
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GO:0001937
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negative regulation of endothelial cell proliferation
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GO:0016525
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negative regulation of angiogenesis
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GO:0030948
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negative regulation of vascular endothelial growth factor receptor signaling pathway
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GO:0051216
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cartilage development
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Cellular Component |
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PDB ID |
MGI:1341171
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InterPro |
IPR007084
BRICHOS domain
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PFAM |
PF04089
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PRINTS |
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PIRSF |
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SMART |
SM01039
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z1F6
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
16840
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UniGene |
Mm.46561
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RefSeq |
NP_034831
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MGI ID |
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MGI Symbol |
Lect1
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OMIM |
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CCDS |
CCDS27302
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HPRD |
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IMGT |
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EMBL |
AK013975
BC045152
CH466535
U43509
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GenPept |
AAD00027
AAH45152
BAB29095
EDL35758
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