InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Skiv2l2

Summary

InnateDB Protein

IDBP-183093.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Skiv2l2

Protein Name

superkiller viralicidic activity 2-like 2 (S. cerevisiae)

Synonyms

2610528A15Rik; mKIAA0052;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022281

InnateDB Gene

IDBG-183091 (Skiv2l2)

Protein Structure

UniProt Annotation

Function

May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000460	maturation of 5.8S rRNA
GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0000178	exosome (RNase complex)
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

MGI:1919448

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR012961 DSH, C-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR016438 RNA helicase, ATP-dependent, SK12/DOB1
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270
PF08148

PRINTS

PIRSF

PIRSF005198

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt