Version 5.4
Mus musculus Protein: Ccdc135
Summary
InnateDB Protein IDBP-183180.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccdc135
Protein Name coiled-coil domain containing 135
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000053972
InnateDB Gene IDBG-183178 (Ccdc135)
Protein Structure
UniProt Annotation
Function May be involved in sperm motility (By similarity). Plays a role in the regulation of germ cells differentiation during spermatogenesis, particularly during meiosis and spermiogenesis. {ECO:0000250, ECO:0000269PubMed:16804880}.
Subcellular Localization Cell projection, cilium, flagellum {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is expressed in diplotene and pachytene spermytocytes, and in round and elongating spermatids (at protein level). Isoform 1 is strongly expressed in spleen and testis, faintly expressed in kidney, ovary and thymus. Isoform 1 is expressed in diplotene and pachytene spermytocytes, round and elongating spermatids. Expressed in testis, kidney, ovary, thymus and spleen. Expressed in ciliated cells. {ECO:0000269PubMed:15156272, ECO:0000269PubMed:16804880, ECO:0000269PubMed:17971504}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007283 spermatogenesis
GO:0008150 biological_process
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005929 cilium
Protein Structure and Domains
PDB ID MGI:2685616
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6V3W6
PhosphoSite PhosphoSite-Q6V3W6
TrEMBL
UniProt Splice Variant
Entrez Gene 330830
UniGene Mm.277112
RefSeq NP_001036180
MGI ID
MGI Symbol Ccdc135
OMIM
CCDS CCDS40444
HPRD
IMGT
EMBL AC103935 AY352586 BC117982 BC117983 CH466525
GenPept AAI17983 AAI17984 AAQ55489 EDL11157

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca