InnateDB Protein
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IDBP-183554.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppp1r15a
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Protein Name
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protein phosphatase 1, regulatory (inhibitor) subunit 15A
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Synonyms
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9630030H21; Gadd34; Myd116;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000049488
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InnateDB Gene
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IDBG-183552 (Ppp1r15a)
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Protein Structure
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Function |
Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. In case of infection with vesicular stomatitis virus (VSV), impairs viral replication. {ECO:0000269PubMed:11381086, ECO:0000269PubMed:12606582, ECO:0000269PubMed:12824288, ECO:0000269PubMed:16478986, ECO:0000269PubMed:17670836}.
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Subcellular Localization |
Endoplasmic reticulum {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed strongly in spleen and lung, moderately in thymus and muscle, and weakly in brain. {ECO:0000269PubMed:12824288}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
31 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1927072
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InterPro |
IPR019523
Protein phosphatase 1, regulatory subunit 15A/B, C-terminal
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PFAM |
PF10488
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P17564
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PhosphoSite |
PhosphoSite-
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TrEMBL |
B2RRL7
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UniProt Splice Variant |
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Entrez Gene |
17872
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UniGene |
Mm.4048
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RefSeq |
NP_032680
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MGI ID |
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MGI Symbol |
Ppp1r15a
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OMIM |
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CCDS |
CCDS21249
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HPRD |
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IMGT |
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EMBL |
AK079339
AK154697
AK167317
BC138485
BC138486
CH466603
X51829
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GenPept |
AAI38486
AAI38487
BAC37613
BAE32770
BAE39419
CAA36128
EDL22865
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