InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scmh1

Summary

InnateDB Protein

IDBP-183610.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scmh1

Protein Name

sex comb on midleg homolog 1

Synonyms

AI315320; AI851618; Scml1; Scml3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069813

InnateDB Gene

IDBG-183606 (Scmh1)

Protein Structure

UniProt Annotation

Function

Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Most abundant in testis. Moderate levels detected in heart, brain, lung, liver, skeletal muscle and kidney and lower levels in spleen. {ECO:0000269PubMed:10653359}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0009952	anterior/posterior pattern specification
GO:0016458	gene silencing
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0010369	chromocenter

Protein Structure and Domains

PDB ID

MGI:1352762

InterPro

IPR001660 Sterile alpha motif domain
IPR004092 Mbt repeat
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
IPR021987 Protein of unknown function DUF3588

PFAM

PF02820
PF07647
PF00536
PF12140

PRINTS

PIRSF

SMART

SM00454
SM00561

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K214