InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctps

Summary

InnateDB Protein

IDBP-183730.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctps

Protein Name

cytidine 5'-triphosphate synthase

Synonyms

Ctps1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030381

InnateDB Gene

IDBG-183728 (Ctps)

Protein Structure

UniProt Annotation

Function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003883	CTP synthase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006541	glutamine metabolic process
GO:0044210	'de novo' CTP biosynthetic process

Cellular Component

GO:0005575	cellular_component
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1858304

InterPro

IPR004468 CTP synthase
IPR011697 Peptidase C26
IPR017456 CTP synthase, N-terminal
IPR017926 Glutamine amidotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029062 Class I glutamine amidotransferase-like

PFAM

PF07722
PF06418
PF00117

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70698

PhosphoSite