Version 5.4
Mus musculus Protein: Agpat9
Summary
InnateDB Protein IDBP-183808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agpat9
Protein Name 1-acylglycerol-3-phosphate O-acyltransferase 9
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000090667
InnateDB Gene IDBG-183804 (Agpat9)
Protein Structure
UniProt Annotation
Function May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid, or PA). {ECO:0000269PubMed:17170135}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:17170135}; Multi-pass membrane protein {ECO:0000269PubMed:17170135}.
Disease Associations
Tissue Specificity Most abundant in epididymal fat, followed by small intestine, brown adipose tissue, kidney, heart and colon. {ECO:0000269PubMed:17170135}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0004366 glycerol-3-phosphate O-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0008152 metabolic process
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0019432 triglyceride biosynthetic process
GO:0032006 regulation of TOR signaling
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:3603816
InterPro IPR002123 Phospholipid/glycerol acyltransferase
PFAM PF01553
PRINTS
PIRSF
SMART SM00563
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C0N2
PhosphoSite PhosphoSite-Q8C0N2
TrEMBL
UniProt Splice Variant
Entrez Gene 231510
UniGene Mm.482473
RefSeq
MGI ID
MGI Symbol Agpat9
OMIM
CCDS CCDS19470
HPRD
IMGT
EMBL AK030171 AK138410 AK160261 BC096769 BC138228 BC145669
GenPept AAH96769 AAI38229 AAI45670 BAC26820 BAE23647 BAE35719

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca