InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lass5

Summary

InnateDB Protein

IDBP-183857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lass5

Protein Name

LAG1 homolog, ceramide synthase 5

Synonyms

2310081H14Rik; AU045339; AW544927; Lass5; Trh4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023762

InnateDB Gene

IDBG-183855 (Lass5)

Protein Structure

UniProt Annotation

Function

Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1. {ECO:0000269PubMed:12912983, ECO:0000269PubMed:16100120}.

Subcellular Localization

Nucleus membrane {ECO:0000255PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269PubMed:12912983}; Multi-pass membrane protein {ECO:0000269PubMed:12912983}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in testis and kidney. {ECO:0000269PubMed:12912983, ECO:0000269PubMed:15823095}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0050291	sphingosine N-acyltransferase activity