InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itga2

Summary

InnateDB Protein

IDBP-183907.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itga2

Protein Name

integrin alpha 2

Synonyms

CD49B; DX5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053891

InnateDB Gene

IDBG-183905 (Itga2)

Protein Structure

UniProt Annotation

Function

Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0032403	protein complex binding
GO:0038064	collagen receptor activity
GO:0043236	laminin binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001894	tissue homeostasis
GO:0002687	positive regulation of leukocyte migration
GO:0006928	cellular component movement
GO:0006929	substrate-dependent cell migration
GO:0006971	hypotonic response
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0008283	cell proliferation
GO:0009612	response to mechanical stimulus
GO:0010634	positive regulation of epithelial cell migration
GO:0010694	positive regulation of alkaline phosphatase activity
GO:0014070	response to organic cyclic compound
GO:0014075	response to amine
GO:0014850	response to muscle activity
GO:0014911	positive regulation of smooth muscle cell migration
GO:0030879	mammary gland development
GO:0031346	positive regulation of cell projection organization
GO:0031589	cell-substrate adhesion
GO:0032870	cellular response to hormone stimulus
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033343	positive regulation of collagen binding
GO:0033591	response to L-ascorbic acid
GO:0033627	cell adhesion mediated by integrin
GO:0038065	collagen-activated signaling pathway
GO:0042060	wound healing
GO:0042493	response to drug
GO:0043388	positive regulation of DNA binding
GO:0043589	skin morphogenesis
GO:0045184	establishment of protein localization
GO:0045727	positive regulation of translation
GO:0045785	positive regulation of cell adhesion
GO:0045987	positive regulation of smooth muscle contraction
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0050927	positive regulation of positive chemotaxis
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0051971	positive regulation of transmission of nerve impulse
GO:0060100	positive regulation of phagocytosis, engulfment
GO:0070365	hepatocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009279	cell outer membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0030424	axon
GO:0042995	cell projection
GO:0043679	axon terminus
GO:0045178	basal part of cell
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:96600

InterPro

IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

PFAM

PF00092
PF01839
PF14312
PF08441
PF00357

PRINTS

PR01185

PIRSF

SMART

SM00327
SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt