InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD151

Summary

InnateDB Protein

IDBP-18405.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD151

Protein Name

CD151 molecule (Raph blood group)

Synonyms

GP27; MER2; PETA-3; RAPH; SFA1; TSPAN24;

Species

Homo sapiens

Ensembl Protein

ENSP00000324101

InnateDB Gene

IDBG-18403 (CD151)

Protein Structure

UniProt Annotation

Function

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. {ECO:0000269PubMed:15265795}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]: A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor. {ECO:0000269PubMed:15265795}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes. {ECO:0000269PubMed:15265795}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0030198	extracellular matrix organization
GO:0031581	hemidesmosome assembly
GO:0034329	cell junction assembly

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000301 Tetraspanin
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin

PFAM

PF00335

PRINTS

PR00259

PIRSF

PIRSF002419

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48509

PhosphoSite

PhosphoSite-P48509

TrEMBL

K4DIB7

UniProt Splice Variant

Entrez Gene

977

UniGene

Hs.654379

RefSeq

NP_620598

HUGO

HGNC:1630

OMIM

602243

CCDS

CCDS7719

HPRD

03763

IMGT

EMBL

AF315942 AK293073 AP006621 AP006623 BC001374 BC013302 BT007397 BT020132 CH471158 CR456826 CR542098 D29963 DQ074789 U14650

GenPept

AAA87064 AAH01374 AAH13302 AAK14179 AAP36061 AAV38934 AAY68211 BAA06229 BAF85762 CAG33107 CAG46895 EAX02400 EAX02402 EAX02406 EAX02407