Version 5.4
Mus musculus Protein: Ndrg4
Summary
InnateDB Protein IDBP-184060.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ndrg4
Protein Name N-myc downstream regulated gene 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036226
InnateDB Gene IDBG-184058 (Ndrg4)
Protein Structure
UniProt Annotation
Function Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor- induced ERK1 and ERK2 phosphorylation. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. {ECO:0000269PubMed:21636852}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in the brain (at protein level). Detected in neurons of various parts of brain, including the olfactory bulb, olfactory tuberculum, cerebral cortex, striatum, hippocampus, dentate gyrus, thalamus, hypothalamus, mesencephalon, cerebellum, pons and medulla oblongata. {ECO:0000269PubMed:21636852}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:2384590
InterPro IPR004142 NDRG
IPR029058 Alpha/Beta hydrolase fold
PFAM PF03096
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BTG7
PhosphoSite PhosphoSite-Q8BTG7
TrEMBL E0CZ50
UniProt Splice Variant
Entrez Gene 234593
UniGene Mm.394553
RefSeq XP_006530930
MGI ID
MGI Symbol Ndrg4
OMIM
CCDS
HPRD
IMGT
EMBL AC113951 AK090374 AK129305 AK168873 BC006595
GenPept AAH06595 BAC41189 BAC98115 BAE40691

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca