Version 5.4
Mus musculus Protein: Neu4
Summary
InnateDB Protein IDBP-184118.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Neu4
Protein Name sialidase 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000051151
InnateDB Gene IDBG-184116 (Neu4)
Protein Structure
UniProt Annotation
Function May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed predominantly in brain. {ECO:0000269PubMed:14637003}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004308 exo-alpha-sialidase activity
GO:0005515 protein binding
GO:0052794 exo-alpha-(2->3)-sialidase activity
GO:0052795 exo-alpha-(2->6)-sialidase activity
GO:0052796 exo-alpha-(2->8)-sialidase activity
Biological Process
GO:0006516 glycoprotein catabolic process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0019866 organelle inner membrane
Protein Structure and Domains
PDB ID MGI:2661364
InterPro IPR011040 Sialidases
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BZL1
PhosphoSite PhosphoSite-Q8BZL1
TrEMBL
UniProt Splice Variant
Entrez Gene 241159
UniGene Mm.214565
RefSeq NP_776133
MGI ID
MGI Symbol Neu4
OMIM
CCDS CCDS15199
HPRD
IMGT
EMBL AK034236 AY258421 BC070438
GenPept AAH70438 AAP81169 BAC28641

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca