InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: 1700027A23Rik

Summary

InnateDB Protein

IDBP-184168.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

1700027A23Rik

Protein Name

RIKEN cDNA 1700027A23 gene

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010280

InnateDB Gene

IDBG-184166 (1700027A23Rik)

Protein Structure

UniProt Annotation

Function

During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner. {ECO:0000269PubMed:20643351}.

Subcellular Localization

Isoform 1: Golgi apparatus, Golgi stack. Golgi apparatus, trans-Golgi network.Isoform 2: Nucleus.Cytoplasm {ECO:0000269PubMed:20643351}. Cytoplasmic vesicle {ECO:0000269PubMed:20643351}. Note=Accumulates specifically at the basal body and ciliary necklace during the early steps of cilia assembly and disassembly, when structural, functional and regulatory proteins are delivered to cilia. At S phase, accumulates in vesicles and declines during mitosis. In node pit cells, found close to the ciliary membrane along the axoneme. In spermatocytes, localizes to particles along the stabilized microtubules of tails.

Disease Associations

Tissue Specificity

Expressed in tissues rich in ciliated cells, such as lung, kidney, vas deferens and testis. Both isoforms 1 and 2 are expressed in testis. {ECO:0000269PubMed:20643351}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017137	Rab GTPase binding
GO:0019894	kinesin binding
GO:0019901	protein kinase binding
GO:0043015	gamma-tubulin binding
GO:0048487	beta-tubulin binding