InnateDB Protein
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IDBP-184541.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppt1
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Protein Name
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palmitoyl-protein thioesterase 1
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Synonyms
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9530043G02Rik; AA960502; C77813; CLN1; D4Ertd184e; INCL; PPT;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000030412
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InnateDB Gene
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IDBG-184539 (Ppt1)
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Protein Structure
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|
Function |
Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
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Subcellular Localization |
Lysosome.
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Disease Associations |
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Tissue Specificity |
Highest level in testis and kidney, lower in heart, brain and lung and lowest in skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0008474
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palmitoyl-(protein) hydrolase activity
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GO:0016290
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palmitoyl-CoA hydrolase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1298204
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InterPro |
IPR002472
Palmitoyl protein thioesterase
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF02089
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PRINTS |
PR00414
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O88531
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PhosphoSite |
PhosphoSite-O88531
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TrEMBL |
Q8VBX5
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UniProt Splice Variant |
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Entrez Gene |
19063
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UniGene |
Mm.452338
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RefSeq |
NP_032943
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MGI ID |
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MGI Symbol |
Ppt1
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OMIM |
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CCDS |
CCDS38870
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HPRD |
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IMGT |
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EMBL |
AF071025
AF087568
AF326557
AF326558
AK014561
AK152474
AK153106
BX545849
CH466552
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GenPept |
AAC25398
AAD25224
AAL37403
AAL37404
BAE31248
BAE31725
EDL30401
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