InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc38a7

Summary

InnateDB Protein

IDBP-184584.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc38a7

Protein Name

solute carrier family 38, member 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037023

InnateDB Gene

IDBG-184582 (Slc38a7)

Protein Structure

UniProt Annotation

Function

Mediates sodium-dependent transport of amino acids. Substrate preference is ranked l-glutamine > l-histidine > l- serine > l-alanine > l-aspargine > l-aspartic acid > l-glutamic acid > l-methionine > l-leucine > l-glycine. {ECO:0000269PubMed:21511949}.

Subcellular Localization

Membrane {ECO:0000269PubMed:21511949}; Multi-pass membrane protein {ECO:0000269PubMed:21511949}. Note=In neurons, located in soma and axons.

Disease Associations

Tissue Specificity

Highly expressed in the brain, including the hippocampus, especially in the granular layer of dentate gyrus cells and the pyramidal cell layer of the hippocampus, amygdala, thalamus, hypothalamus, in the layer of Purkinje cells in the cerebellum and the layers of cortex. Particularly strong expression in neurons of the ventromedial hypothalamus, basolateral amygdala, ventral tegmental area, and locus coeruleus. Not detected in glial cells, including astrocytes. In addition to brain, also expressed in the spinal cord (at protein level). {ECO:0000269PubMed:21511949}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005290	L-histidine transmembrane transporter activity
GO:0005313	L-glutamate transmembrane transporter activity
GO:0015179	L-amino acid transmembrane transporter activity
GO:0015180	L-alanine transmembrane transporter activity
GO:0015182	L-asparagine transmembrane transporter activity
GO:0015183	L-aspartate transmembrane transporter activity
GO:0015186	L-glutamine transmembrane transporter activity
GO:0015190	L-leucine transmembrane transporter activity
GO:0015191	L-methionine transmembrane transporter activity
GO:0015194	L-serine transmembrane transporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006814	sodium ion transport
GO:0006867	asparagine transport
GO:0006868	glutamine transport
GO:0015803	branched-chain amino acid transport
GO:0015804	neutral amino acid transport
GO:0015807	L-amino acid transport
GO:0015808	L-alanine transport
GO:0015810	aspartate transport
GO:0015813	L-glutamate transport
GO:0015817	histidine transport
GO:0015821	methionine transport
GO:0015825	L-serine transport
GO:1902475	L-alpha-amino acid transmembrane transport