InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctnnd1

Summary

InnateDB Protein

IDBP-184772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctnnd1

Protein Name

catenin (cadherin associated protein), delta 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065252

InnateDB Gene

IDBG-184766 (Ctnnd1)

Protein Structure

UniProt Annotation

Function

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. {ECO:0000250, ECO:0000269PubMed:15138284, ECO:0000269PubMed:15817151, ECO:0000269PubMed:17344476}.

Subcellular Localization

Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation. Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005488	binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0045296	cadherin binding

Biological Process

GO:0001738	morphogenesis of a polarized epithelium
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007155	cell adhesion
GO:0007420	brain development
GO:0007435	salivary gland morphogenesis
GO:0016055	Wnt signaling pathway
GO:0016337	single organismal cell-cell adhesion
GO:0030216	keratinocyte differentiation
GO:0060690	epithelial cell differentiation involved in salivary gland development
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0005915	zonula adherens
GO:0005923	tight junction
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030426	growth cone
GO:0030496	midbody
GO:0043197	dendritic spine
GO:0045202	synapse