Version 5.4
Mus musculus Protein: Scel
Summary
InnateDB Protein IDBP-185128.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scel
Protein Name sciellin
Synonyms 9230114I02Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000093233
InnateDB Gene IDBG-185126 (Scel)
Protein Structure
UniProt Annotation
Function May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Membrane. Note=May become cross- linked to membrane proteins by transglutaminase.
Disease Associations
Tissue Specificity Expressed in the upper layers of stratified epithelia, including, ependyma and choroid plexus of the brain ventricles.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0008544 epidermis development
GO:0009790 embryo development
GO:0030216 keratinocyte differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1891228
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EQG3
PhosphoSite PhosphoSite-Q9EQG3
TrEMBL Q14DU0
UniProt Splice Variant
Entrez Gene 64929
UniGene Mm.244003
RefSeq NP_075024
MGI ID
MGI Symbol Scel
OMIM
CCDS CCDS37002
HPRD
IMGT
EMBL AF245700 AK020346 BC111874 BC112380 CH466544
GenPept AAG40727 AAI11875 AAI12381 BAB32078 EDL00501

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca