InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Timm10

Summary

InnateDB Protein

IDBP-185412.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Timm10

Protein Name

translocase of inner mitochondrial membrane 10 homolog (yeast)

Synonyms

Tim13; Timm13a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028470

InnateDB Gene

IDBG-185410 (Timm10)

Protein Structure

UniProt Annotation

Function

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0051087	chaperone binding

Biological Process

GO:0045039	protein import into mitochondrial inner membrane
GO:0072321	chaperone-mediated protein transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0042719	mitochondrial intermembrane space protein transporter complex

Protein Structure and Domains

PDB ID

MGI:1353429

InterPro

IPR004217 Tim10/DDP family zinc finger

PFAM

PF02953

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P62073

PhosphoSite

PhosphoSite-P62073

TrEMBL

UniProt Splice Variant

Entrez Gene

30059

UniGene

RefSeq

NP_038927

MGI ID

MGI Symbol

Timm10

OMIM

CCDS

CCDS38161

HPRD

IMGT

EMBL

AF150090 AK008088 BC031448

GenPept

AAD39996 AAH31448 BAB25452