InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prg3

Summary

InnateDB Protein

IDBP-185645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prg3

Protein Name

proteoglycan 3

Synonyms

MBP2; MBPH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028466

InnateDB Gene

IDBG-185643 (Prg3)

Protein Structure

UniProt Annotation

Function

Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. {ECO:0000250}.

Subcellular Localization

Note=Localized to the eosinophil secondary granule. {ECO:0000269PubMed:10770291}.

Disease Associations

Tissue Specificity

Expressed in bone marrow, spleen, and thymus. Not detected in heart, liver or lung. {ECO:0000269PubMed:10770291}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030246	carbohydrate binding

Biological Process

GO:0001694	histamine biosynthetic process
GO:0006955	immune response
GO:0017148	negative regulation of translation
GO:0019370	leukotriene biosynthetic process
GO:0042119	neutrophil activation
GO:0042554	superoxide anion generation
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0045575	basophil activation