Version 5.4
Homo sapiens Protein: TPST1
Summary
InnateDB Protein IDBP-18617.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPST1
Protein Name tyrosylprotein sulfotransferase 1
Synonyms TANGO13A;
Species Homo sapiens
Ensembl Protein ENSP00000302413
InnateDB Gene IDBG-18615 (TPST1)
Protein Structure
UniProt Annotation
Function Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0008476 protein-tyrosine sulfotransferase activity
Biological Process
GO:0006478 peptidyl-tyrosine sulfation
GO:0006954 inflammatory response
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00685
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60507
PhosphoSite PhosphoSite-O60507
TrEMBL Q75ML6
UniProt Splice Variant
Entrez Gene 8460
UniGene Hs.421194
RefSeq NP_003587
HUGO HGNC:12020
OMIM 603125
CCDS CCDS5533
HPRD 07216
IMGT
EMBL AC008267 AC026281 AC079855 AF038009 AK313098 BC013188 CH236961 CH471140 CR542060 CR542080
GenPept AAC13552 AAH13188 AAS02012 AAS07522 BAG35922 CAG46857 CAG46877 EAL23739 EAX07937 EAX07938

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca